GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs798766 | 1 | rs11732213 | chr4:1704244 | FAM53A | chr4:1641609-1685854:- | 0.29 | 4.12 | 4.66E-5 | Urinary bladder cancer;Bladder cancer |
| BLCA | cis | rs2412488 | 1 | rs11734039 | chr4:54264428 | SCFD2 | chr4:53739152-54232242:- | 0.25 | 3.86 | 0.000134 | DNA methylation (variation) |
| BLCA | cis | rs10461617 | 1 | rs11739344 | chr5:56111087 | C5orf35 | chr5:56205103-56213010:+ | 0.72 | 10.68 | 1.81E-23 | Type 2 diabetes |
| BLCA | cis | rs7714584 | 1 | rs11739619 | chr5:150264662 | LOC134466 | chr5:150310000-150326146:- | 0.47 | 6.24 | 1.17E-9 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs11739677 | chr5:150294883 | LOC134466 | chr5:150310000-150326146:- | 0.55 | 6.83 | 3.35E-11 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs11740172 | chr5:150300278 | LOC134466 | chr5:150310000-150326146:- | 0.55 | 6.86 | 2.73E-11 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs11741861 | chr5:150277909 | LOC134466 | chr5:150310000-150326146:- | -0.53 | -6.64 | 1.07E-10 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs11743488 | chr5:150279218 | LOC134466 | chr5:150310000-150326146:- | 0.57 | 6.9 | 2.1E-11 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs11746108 | chr5:150264622 | LOC134466 | chr5:150310000-150326146:- | 0.47 | 6.24 | 1.17E-9 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs11746807 | chr5:150300419 | LOC134466 | chr5:150310000-150326146:- | 0.55 | 6.85 | 2.96E-11 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs11747065 | chr5:150295486 | LOC134466 | chr5:150310000-150326146:- | 0.55 | 6.86 | 2.73E-11 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs11747270 | chr5:150258867 | LOC134466 | chr5:150310000-150326146:- | -0.45 | -5.91 | 7.53E-9 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs11748151 | chr5:150226292 | LOC134466 | chr5:150310000-150326146:- | 0.43 | 5.33 | 1.71E-7 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs11748158 | chr5:150226345 | LOC134466 | chr5:150310000-150326146:- | 0.43 | 5.33 | 1.71E-7 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs11749391 | chr5:150229066 | LOC134466 | chr5:150310000-150326146:- | 0.43 | 5.35 | 1.52E-7 | Crohn's disease |